Worse Prostate Cancer Outcomes With 5-Alpha-Reductase Inhibitors

 · Another alternative is to use a 5-alpha reductase inhibitor (finasteride or dutasteride) that reduces the risk of getting prostate cancer by 25 to 30 percent, smoothes out fluctuations in PSA, and makes PSA a better screening test for cancer.

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 · This study demonstrates that among Gleason 8-10 prostate cancers, some of the worst survival outcomes are associated with the lowest PSA levels.

A recent study found prior use of 5-alpha-reductase inhibitors for benign prostatic hyperplasia was associated with delayed prostate cancer diagnosis and worse prostate cancer outcomes. &ldquo.

ASCO 2018: Abiraterone May Be More Effective in Black Men. – “Black men are more than twice as likely to die of prostate cancer than white men and are generally thought to have worse prostate cancer outcomes. Our study suggests that when black men and white men with advanced prostate cancer are given the same hormone treatment, this is not the case,” said lead study author Daniel George, MD.

The 5-alpha reductase inhibitors are a family of agents used to treat benign prostatic hypertrophy. They act by inhibiting the steroid 5-alpha reductase which catalyzes the conversion of testosterone to dihydrotestosterone. Dihydrotestosterone is an important prostatic growth factor and its inhibition causes gradual shrinkage of prostate.

 · Another hypothesized technical mechanism for worse prostate-specific outcomes with increasing BMI is the use of lower radiation doses in the treatment of prostate cancer in previous studies with the median radiation dose often at 70Gy or below 10, 11.

April 11 (UPI) –A common prostate cancer drug has been linked to type 2 diabetes, a new study says. Men taking 5-alpha-reductase inhibitors had the risk of. studies to better understand the.

5-alpha-reductase inhibitors delay prostate cancer diagnosis. – 5-alpha-reductase inhibitors delay prostate cancer diagnosis, worsen outcomes 19 days ago – By Healio. A recent study found prior use of 5-alpha-reductase inhibitors for benign prostatic hyperplasia was associated with delayed prostate cancer diagnosis and worse prostate cancer outcomes.

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5-alpha reductase inhibitors; Lower urinary tract symptoms Abstract Benign prostatic hyperplasia (BPH) is characterized by an enlarged prostate, lower urinary tract symptoms (LUTS), and a decreased urinary ow rate. Common in older men, BPH is a progressive disease that can eventually lead to complications including acute urinary

Worse prostate cancer outcomes with 5-alpha-reductase inhibitors May 09, 2019 source: Reuters Health News Treatment with 5-alpha-reductase inhibitors (5-ARIs) is associated with shorter time to diagnosis and worse mortality in prostate cancer, according to findings from veterans affairs electronic health records.